Identifiers
dual specificity phosphatase 1
HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562
HUGO:DUSP1
PTPN10
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
synonym:MKP-1
PMID:16184516
In silico??analysis identified a STAT6 binding site at position +99 (relative to the transcriptional start site) of the mouse DUSP1 promoter.??
MKP-1 (DUSP1) preferentially inactivates JNK and P38.
DUSP1 play its phosphatase role in the nucleus.
PMID:19436832 PMID:17496916
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
References
rc_re1395:( Regulated Cell Death ) reactionType:is.a
References
in_re929( Innate Immunity ):
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
in_re930( Innate Immunity ):
PMID:11875494
IL10-induced p38 phosphorylation.
PMID:20435894
SHIP inhibit MAPKp38 activation and prevent
MKNK1 phosphorylation by inhibiting the p38MAPK
pathway downstream of IL10.
PMID:10925299
IL13 induces p38 MAPK phosphorilation and activation, p38 MAPK participates in arginase activation??downstream of IL13.
PMID:23508573
HMGB1 induces activation (phosphorylation) of p38 via TLR4.
PMID:12811837, PMID:16713974
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.
References
su_mpk1_mpk1_re184( Survival ):
TNF-induced ROS cause oxidation and inhibition of DUSP1 and DUSP5.
PMID:15766528
References
su_mpk1_mpk1_re221:( Survival ) Translation
su_mpk1_mpk1_re180( Survival ):
MKP-1 (DUSP1) preferentially inactivates JNK and P38.
PMID:19436832
su_mpk1_mpk1_re184( Survival ):
TNF-induced ROS cause oxidation and inhibition of DUSP1 and DUSP5.
PMID:15766528