Identifiers
neutral sphingomyelinase (N-SMase) activation associated factor
HUGO:NSMAF HGNC:8017 ENTREZ:8439 UNIPROT:Q92636
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / TNF_RESPONSE
References
PMID:12404124
PMID:11435466
PMID:16716889
PMID:28765050
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / TNF_RESPONSE
References
rc_re1744( Regulated Cell Death ):
PMID:11279185
Stimulation via CD95 or CD40 activates ASM and triggers a translocation of the enzyme onto the cell surface
PMID:12531547
PMID:8663014
Upon ligation of TNF-??, TNF-R1 recruits FAN through its N-SMase activation domain (NSD) and activates N-SMase
PMID:1330325
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown.
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / TNF_RESPONSE
References
rc_re1565( Regulated Cell Death ):
PMID:12404124
nitric oxide inhibits acid and neutral sphingomyelinases through generation of cyclic GMP and activation of protein kinase G
PMID:9393753
The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
PMID:26801188