Protein SMPD1 map

Identifiers
sphingomyelin phosphodiesterase 1, acid lysosomal
HUGO:SMPD1 HGNC:11120 ENTREZ:6609 UNIPROT:P17405

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 RECON2  map

References
PMID:16716889
Upon ligation of TNF-??, TNF-R1 recruits FAN through its N-SMase activation domain (NSD) and activates N-SMase
PMID:12531547
PMID:8663014

SMPD1@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1744( Regulated Cell Death  map ):
PMID:11279185
Stimulation via CD95 or CD40 activates ASM and triggers a translocation of the enzyme onto the cell surface
PMID:12531547
PMID:8663014
Upon ligation of TNF-??, TNF-R1 recruits FAN through its N-SMase activation domain (NSD) and activates N-SMase
PMID:1330325
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown.

Modifications:
In compartment: Cytosol
  1. SMPD1@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. NSMAF:​SMPD1@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NSMAF@Cytosol map + SMPD1@Cytosol map → map NSMAF:​SMPD1@Cytosol map
As Catalyser:
  1. Sphingomyelin@Cytosol map + H2O@Cytosol map → map Ceramide@Cytosol map + Choline Phosphate@Cytosol map
  2. Sphingomyelin@Cytosol map → map Ceramide@Cytosol map