Catalysis

1. TNFRSF1A|​hm3:​TNF|​hm3@TNFRSF1 Receptor Complex

References
PMID:11279185
Stimulation via CD95 or CD40 activates ASM and triggers a translocation of the enzyme onto the cell surface
PMID:12531547
PMID:8663014
Upon ligation of TNF-??, TNF-R1 recruits FAN through its N-SMase activation domain (NSD) and activates N-SMase
PMID:1330325
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown.