Protein GZMA map

Identifiers
HUGO:GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HUGO:GZMA HGNC:4708 ENTREZ:3001 UNIPROT:P12544

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
PMID:14499263 PMID:8432729
 NATURAL_KILLER  map
CASCADE:IL15
PMID:16106370, PMID:15607806
Five granzymes are expressed in human NK cells (Grz A, B, H, K and M)
GrzA and GrzK are trypsins (cleaving at basic residues arginine and lysine)
GrzB is an aspase, cleaving after aspartic acid residues, and GrzH is a chymase, cleaving after hydrophobic residues such as phenylalanine.
GrzM has a unique enzyme specificity, preferring cleavage after methionine, leucine, or isoleucine.
PMID:11413196, PMID:11413196
VAV1 induces granule exocytosis of granzyme A probably via RAC1-ERK pathway. The absence of Vav1 results in defective granule exocytosis and reduced ability to lyse tumor targets.

GZMA@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re68:( Regulated Cell Death  map ) PMID:18485875

GZMA@Immunological Synapse

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

Modifications:
In compartment: Cytosol
  1. GZMA@Cytosol map
In compartment: Immunological Synapse
  1. GZMA@Immunological Synapse map
In compartment: Lytic granule
  1. GZMA@Lytic granule map
In compartment: SECRETORY_GRANULE
  1. GZMA@SECRETORY_GRANULE map
In compartment: default
  1. GZMA@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rGZMA@T_cell map → map GZMA@Lytic granule map
    2. GZMA@Lytic granule map → map GZMA@default map
    3. GZMA@SECRETORY_GRANULE map → map GZMA@default map
    4. GZMA@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    5. rGZMA@INNATE_IMMUNE_CELL_Cytosol map → map GZMA@SECRETORY_GRANULE map
    6. GZMA@Immunological Synapse map → map GZMA@Cytosol map
    As Catalyser:
    1. FMN:​MT-ND1:​MT-ND2:​MT-ND3:​MT-ND4:​MT-ND4L:​MT-ND5:​MT-ND6:​NDUFA1:​NDUFA10:​NDUFA11:​NDUFA12:​NDUFA13:​NDUFA2:​NDUFA3:​NDUFA4:​NDUFA5:​NDUFA6:​NDUFA7:​NDUFA8:​NDUFA9:​NDUFAB1:​NDUFB1:​NDUFB10:​NDUFB11:​NDUFB2:​NDUFB3:​NDUFB4:​NDUFB5:​NDUFB6:​NDUFB7:​NDUFB8:​NDUFB9:​NDUFC1:​NDUFC2:​NDUFS1|​[2Fe-2S],[4Fe-4S],[4Fe-4S]:​NDUFS2:​NDUFS3:​NDUFS4:​NDUFS5:​NDUFS6:​NDUFS7|​[4Fe-4S]:​NDUFS8|​[4Fe-4S],[4Fe-4S]:​NDUFV1|​[4Fe-4S]:​NDUFV2|​[2Fe-2S]:​NDUFV3@Mitochondrial inner membrane map → map cleaved~NDUFS3*@Mitochondrial intermembrane space map