Phenotype Fibroblast_proliferation map
Fibroblast_proliferation@Cytosol

References
PMID:16572188
Fibroblasts can acquire an activated phenotype, which is associated with an increased proliferative activity and enhanced secretion of ECM proteins such as type I collagen and tenascin C, and also fibronectin that contains the extra domain a (EDA-fibronectin) and SPARC (secreted protein acidic and rich in cysteine).
PDGF induces the proliferation of fibroblasts, but does not induce the acquisition of an activated phenotype that is associated with excessive ECM deposition.
FGF2 was originally identified as a 'basic fibroblast growth factor', which stimulates the proliferation of 3T3 fibroblasts but not the expression of -smooth-muscle actin.
PMID:12782713
CD74 mediates MIF stimulation of ERK-1/2 (p44/p42) phosphorylation and proliferation of CCL210 human lung fibroblasts.
PMID:22652804
TGF-??1 CM enhanced fibroblast proliferation and
differentiation. FGF-2 is
necessary for the fibroblast proliferation induced by TGF.
. Fibroblast ERK signaling is required for TGF-??1
CM-induced cell differentiation and proliferation

Modifications:
In compartment: Cytosol
  1. Fibroblast_proliferation@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ERK1/2*|​pho@Cytosol map → map Fibroblast_proliferation@Cytosol map
    2. SP1@Cytosol map → map Fibroblast_proliferation@Cytosol map
    3. EGFR:​ERBB*@Cytosol map → map Fibroblast_proliferation@Cytosol map
    4. TGFB*@default map + EGF@default map → map Fibroblast_proliferation@Cytosol map
    5. CTGF@Cytosol map → map Fibroblast_proliferation@Cytosol map
    6. arMIR155@Cytosol map → map Fibroblast_proliferation@Cytosol map
    7. Hypoxia@Cytosol map → map Fibroblast_proliferation@Cytosol map
    8. ca_s4530 → map Fibroblast_proliferation@Cytosol map
    9. (DAG:​PKC*)|​active@Cytosol map → map Fibroblast_proliferation@Cytosol map
    10. lysophostatidic acid@default map → map Fibroblast_proliferation@Cytosol map
    As Catalyser: