Protein RASGRP1 map

Identifiers
HUGO:RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:10807788 PMID:24027568 PMID:14764585 PMID:15184873
RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus.
RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family.
PMID:12782630 PMID:17496910
Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html

RASGRP1@Cytoplasm

References
su_mpk1_mpk1_re46( Survival  map ):
RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family.
PMID:17496910
DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html

Modifications:
In compartment: Cytoplasm
  1. RASGRP1@Cytoplasm map
In compartment: T_cell
  1. RASGRP1@T_cell map
Participates in complexes:
In compartment: Golgi Apparatus
  1. Ca2+:​DAG:​RASGRP1@Golgi Apparatus map
  2. Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  3. Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
In compartment: Plasma Membrane
  1. DAG:​RASGRP1@Plasma Membrane map
  2. Ca2+:​DAG:​RASGRP1@Plasma Membrane map
In compartment: T_cell
  1. DAG:​RASGRP1@T_cell map
Participates in reactions:
As Reactant or Product:
  1. RASGRP1@T_cell map + DAG@T_cell map → map DAG:​RASGRP1@T_cell map
  2. RAS*@Plasma Membrane map + Ca2+:​DAG:​RASGRP1@Golgi Apparatus map → map Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  3. DAG@Plasma Membrane map + RASGRP1@Cytoplasm map → map DAG:​RASGRP1@Plasma Membrane map
  4. DAG:​RASGRP1@Plasma Membrane map + Ca2+@Cytoplasm map → map Ca2+:​DAG:​RASGRP1@Plasma Membrane map
  5. Ca2+:​DAG:​RASGRP1@Plasma Membrane map → map Ca2+:​DAG:​RASGRP1@Golgi Apparatus map
  6. RAF1@Cytoplasm map + Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map → map Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
As Catalyser:
  1. GDP:​HRAS@T_cell map + GTP@T_cell map → map (GTP:​HRAS)|​active@T_cell map + GDP@T_cell map
  2. ERK*:​MEK*:​SEF*@Golgi Apparatus map → map ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map