Protein DR4/5* map

Identifiers
HUGO:TNFRSF10A, HUGO:TNFRSF10A

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
TRAIL receptor 1 and 2
PMID:20531300
PMID:19090789
PMID:9242610

DR4/5*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
rc_re1639:( Regulated Cell Death  map ) PMID:9242610

Modifications:
In compartment: Cytosol
  1. DR4/5*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. DR4/5*:​TRAIL*@Cytosol map
  2. Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  3. DR4/5*:​THBS1:​TRAIL*@Cytosol map
  4. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map
  5. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. DR4/5*:​THBS1:​TRAIL*@Cytosol map → map Apoptosis@Cytosol map
  2. THBS1@Cytosol map + DR4/5*:​TRAIL*@Cytosol map → map DR4/5*:​THBS1:​TRAIL*@Cytosol map
  3. TNFRSF10A@Cytosol map → map DR4/5*@Cytosol map
  4. TNFRSF10B@Cytosol map → map DR4/5*@Cytosol map
  5. TRAIL*@Extracellular space map + DR4/5*@Cytosol map → map DR4/5*:​TRAIL*@Cytosol map
  6. DR4/5*:​TRAIL*@Cytosol map + FADD@Cytosol map → map rc_s5142
  7. rc_s5142 + Caspase8,10*@Cytosol map → map Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  8. CUL3:​RBX1@Cytosol map + Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map → map CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map
  9. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map → map Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  10. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map → map rc_s6308
  11. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map + CFLAR@Cytosol map + RIPK1@Cytosol map + RIPK3@Cytosol map + MLKL@Cytosol map → map CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map + CUL3:​RBX1@Cytosol map
  12. Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map + TRAF2@Cytosol map + IKBKG@Cytosol map + TRADD@Cytosol map + RIPK1@Cytosol map → map Caspase10*:​Caspase8*@Cytosol map
  13. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
As Catalyser:
  1. MAP2K4@Cytosol map → map MAP2K4|​pho@Cytosol map