Protein THBS1 map

Identifiers
HGNC:11785
thrombospondin 1
HUGO:THBS1, HGNC:11785, ENTREZ:7057, UNIPROT:P07996,GENECARDS:GC15P039873
HUGO:THBS1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / ECM  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:11982756
PMID:8349738
THBS1 cleaves the latent TGFB1 complex, releasing TGFB in its active form
PMID:22943793
 DENDRITIC_CELL  map
CASCADE:THBS1
CASCADE:IL10
CASCADE:TGFB
CASCADE:PGE2
PMID:14996710
Thrombospondin-1 is associated with tumor microenvironment.
PMID:10657674
CD47 engagement by Thrombospondin-1 peptide inhibits cytokine production and maturation of human dendritic cells.
PMID:14568985
Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation.
The endogenous TSP produced during early DC activation negatively regulates IL-12, TNF-??, and IL-10 release through its interactions with CD47.
IL-10, TGF-??, and PGE2??enhance TSP secretion by Dcs

THBS1@Extracellular space

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / ECM  map

References
PMID:8349738
THBS1 cleaves the latent TGFB1 complex, releasing TGFB in its active form
PMID:22943793
em_emtc_emtc_re228( EMT Senescence  map ):
PMID:21900405
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP

Modifications:
In compartment: Cytosol
  1. THBS1@Cytosol map
In compartment: Extracellular space
  1. THBS1@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. THBS1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. THBS1@default map
Participates in complexes:
In compartment: Cytosol
  1. DR4/5*:​THBS1:​TRAIL*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD36:​THBS1@INNATE_IMMUNE_CELL_Membrane map
  2. CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. THBS1@Cytosol map → map TSP*@Cytosol map
  2. DR4/5*:​THBS1:​TRAIL*@Cytosol map → map Apoptosis@Cytosol map
  3. THBS1@Cytosol map + DR4/5*:​TRAIL*@Cytosol map → map DR4/5*:​THBS1:​TRAIL*@Cytosol map
  4. THBS1@default map + CD36@INNATE_IMMUNE_CELL_Membrane map → map CD36:​THBS1@INNATE_IMMUNE_CELL_Membrane map
  5. THBS1@INNATE_IMMUNE_CELL_Cytosol map → map THBS1@default map
  6. THBS1@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_SUPRESSION@default map
  7. CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map → map IMMUNE_SUPRESSION@default map
  8. CD47@INNATE_IMMUNE_CELL_Membrane map + THBS1@default map → map CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Quiescence of vasculature@Cytosol map → map Angiogenesis@Cytosol map
  2. FIGF:​KDR:​NRP1:​VEGFC@Cytosol map → map KDR|​Y1175_emp|​1054_pho:​NRP1:​VEGFA:​VEGFB@Cytosol map
  3. MAP2K4@Cytosol map → map MAP2K4|​pho@Cytosol map
  4. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map → map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map