Protein TRAIL* map

Identifiers
HUGO:TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
PMID:20531300
PMID:9242610
PMID:28258062
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.
PMID:8777713
Also known as APO2L, TNFSF10
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
 NEUTROPHIL  map
CASCADE:IFNAB
CASCADE:IFNG
CASCADE:IL12
PMID:9858524
Mature CD56(+) NK cells mediate TRAIL-dependent and FasL-dependent cytotoxicity of tumor cells.
PMID:11257133
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis.
Administration of IL-12 selectively upregulated TRAIL expression on NK cells.
IL-12 stimulates TRAIL-mediated antimetastatic activity of NK cells.
The cytotoxicity of NK cells was inhibited partially by anti-TRAIL mAb.
TRAIL is a key effector molecule mediating the IFNG???dependent antimetastatic effect of IL-12.
IFN-?? induced both liver and spleen NK cell TRAIL expression. By contrast, treatment with either IL-12 or ??-GalCer did not induce NK cell TRAIL. These data directly supported the conclusion that IFN-?? plays a key role in TRAIL expression and TRAIL-mediated antimetastatic function of NK cells.
PMID:11823516
Human immature dendritic cells express on their cell surface four different cytotoxic TNF family ligands: TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis inducing ligand; while cancer cells express the corresponding death receptors. Disruptions of interactions between the four ligands expressed on DCs and corresponding death-signaling receptors expressed on cancer cells using specific Abs or RFc fusion proteins block the cytotoxic activity of DCs directed against cancer cells.
PMID:10811870??
I IFN induces TRAIL mRNA expression in DCs and enhances apoptosis of target tumor cells.
PMID:23510023, PMID:23170255
TRAIL, FASL and TNF provides Dendritic cell tumor killing activity.()
PMID:26819959, PMID:25001536??
Neutrophils kill tumor cells by TRAIL

TRAIL*@Extracellular space

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
rc_re1632:( Regulated Cell Death  map ) PMID:20531300
rc_re1639:( Regulated Cell Death  map ) PMID:9242610

Modifications:
In compartment: Extracellular space
  1. TRAIL*@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TRAIL*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. DR4/5*:​TRAIL*@Cytosol map
  2. DR4/5*:​THBS1:​TRAIL*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. DR4/5*:​THBS1:​TRAIL*@Cytosol map → map Apoptosis@Cytosol map
  2. THBS1@Cytosol map + DR4/5*:​TRAIL*@Cytosol map → map DR4/5*:​THBS1:​TRAIL*@Cytosol map
  3. rTRAIL*@INNATE_IMMUNE_CELL_Cytosol map → map TRAIL*@INNATE_IMMUNE_CELL_Cytosol map
  4. TRAIL*@Extracellular space map + TNFRSF11B@Cytosol map → map rc_s5081
  5. TRAIL*@Extracellular space map + TNFRSF10C@Cytosol map → map rc_s5087
  6. TRAIL*@Extracellular space map + TNFRSF10D@Cytosol map → map rc_s5093
  7. TRAIL*@Extracellular space map + DR4/5*@Cytosol map → map DR4/5*:​TRAIL*@Cytosol map
  8. DR4/5*:​TRAIL*@Cytosol map + FADD@Cytosol map → map rc_s5142
As Catalyser:
  1. MAP2K4@Cytosol map → map MAP2K4|​pho@Cytosol map