Identifiers
microtubule-associated protein 1 light chain 3 alpha
HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 

References
PMID:15325588
PMID:23725295
LC3-I is transformed into LC3-II/Atg8 thanks to Phosphatidyl ethanolamine
PMID:24070470

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 

References
rc_re1768:( Regulated Cell Death  ) PMID:18586673

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 

References
rc_re1789:( Regulated Cell Death  ) PMID:24070470
rc_re1784:( Regulated Cell Death  ) PMID:23725295
rc_re1863( Regulated Cell Death  ):
PMID:20713600
LC3 is phosphorylated by PKA and thus inhibited

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 

References
rc_re1863( Regulated Cell Death  ):
PMID:20713600
LC3 is phosphorylated by PKA and thus inhibited

1. LC3*@Autopagosome

1. LC3*@Autophgosome

1. LC3*@Cytosol
2. LC3*|​pho@Cytosol

1. LC3*:​PIP3*@Autopagosome

1. ATG5:​CASP8|​K63_ubi:​FADD:​LC3*:​SQSTM1 @Autophgosome

1. PIP3*@Autopagosome + LC3*@Autopagosome → LC3*:​PIP3*@Autopagosome
2. ATG8*@Cytosol → LC3*@Cytosol
3. GABARAPL1@Cytosol → LC3*@Cytosol
4. GATE-16*@Cytosol → LC3*@Cytosol
5. LC3*@Cytosol → LC3-I*@Cytosol
6. ATG3:​LC3-I*:​Phosphatidyl ethanolamine@Autopagosome → LC3*@Cytosol
7. LC3*@Cytosol → LC3*|​pho@Cytosol
8. rc_s7531 + SQSTM1 @Autophgosome + LC3*@Autophgosome + ATG5@Autophgosome → ATG5:​CASP8|​K63_ubi:​FADD:​LC3*:​SQSTM1 @Autophgosome
9. ATG5:​CASP8|​K63_ubi:​FADD:​LC3*:​SQSTM1 @Autophgosome → Apoptosis@Cytosol

1. ATG2*@Cytosol → ATG2*:​PIP3*@Autopagosome