Identifiers
HUGO:HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class B member
HUGO:HSPC2, HGNC:5258, ENTREZ:3326, UNIPROT:P08238
heat shock protein 90kDa alpha (cytosolic), class A member 1
HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900
heat shock protein 90kDa alpha (cytosolic), class A member 2
HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568
Heat shock protein 90 kDa alpha class A member 1
HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 GENECARDS:HSP90AA1 REACTOME:56696 KEGG:3320 ATLASONC:GC_HSP90AA1 WIKI:HSP90AA1
Heat shock protein 90 kDa alpha class A member 2
HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568 GENECARDS:HSP90AA2 ATLASONC:GC_HSP90AA2 WIKI:HSP90AA2
Heat shock protein 90 kDa alpha class B member 1
HUGO:HSP90AB1 HGNC:5258 ENTREZ:3326 UNIPROT:P08238 GENECARDS:HSP90AB1 REACTOME:56698 KEGG:3326 ATLASONC:GC_HSP90AB1 WIKI:HSP90AB1
Heat shock protein 90 kDa beta member 1
HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 GENECARDS:HSP90B1 REACTOME:54332 KEGG:7184 ATLASONC:GC_HSP90B1 WIKI:HSP90B1

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair   / HR 
 Cell Cycle DNA Repair   / FANCONI 
 Cell Cycle DNA Repair   / G2_M_CHECKPOINT 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:21945180
PMID:22869732, PMID:17327415
PMID:19387550
PMID:19662498
PMID:18566586
PMID:10995457

References
te_re93:( Telomere Maintenance  ) PMID:10197982 PMID:21945180 PMID:23551398

References
ce_re120( Cell Cycle DNA Repair  ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
ce_re523( Cell Cycle DNA Repair  ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732
ce_re525( Cell Cycle DNA Repair  ):
HSP90 redirects FANCA to degradation, inhibits Fanconi pathway and increases sensitivity to cross-linking agents
PMID:17327415

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 

References
rc_re479:( Regulated Cell Death  ) reactionType:is.a
rc_re386( Regulated Cell Death  ):
PMID:10973499
in vitro reconstitution of the E3-ligase activity, with VHL, elonginB/C, RBX1,CUL2
PMID:18985005
in COS monkey kidney cells and Caki-I human renal carcinoma cells, inhibition of VHL-mediated HIF1A ubiquitinylation and degradation by ectopically expressed constitutively active STAT3
rc_re488:( Regulated Cell Death  ) PMID:10944114
rc_re718:( Regulated Cell Death  ) PMID:14614132
rc_re721:( Regulated Cell Death  ) PMID:12176997
rc_re1149( Regulated Cell Death  ):
PMID:12441346
in murine L929 cell line, RIPK1 is a HSP90 client protein

References
s_akt1_re41( Survival  ):
PMID:19662498
PMID:19387550
PMID:18566586

1. HSP90*@Cytoplasm

1. HSP90*@Cytosol
2. HSP90*|​hm2@Cytosol

1. HSP90*@Nucleus

1. AKT1|​T450_emp|​S473_emp|​S129_pho:​HSP90*@Cytoplasm

1. APAF1:​HSP90*@Cytosol
2. HSP90*|​hm2:​PTGES3:​TERT@Cytosol
3. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Cytosol
4. HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol
5. HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol
6. HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol

1. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Nucleus
2. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus

1. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@cajal body
2. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@cajal body

1. HSP90AA1@Cytosol → HSP90*@Cytosol
2. HSP90AA2@Cytosol → HSP90*@Cytosol
3. HSP90AB1@Cytosol → HSP90*@Cytosol
4. APAF1@Cytosol + HSP90*@Cytosol → APAF1:​HSP90*@Cytosol
5. AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm + HSP90*@Cytoplasm → AKT1|​T450_emp|​S473_emp|​S129_pho:​HSP90*@Cytoplasm
6. AKT1|​T450_emp|​S473_emp|​S129_pho:​HSP90*@Cytoplasm → AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft
7. HSP90*|​hm2:​PTGES3:​TERT@Cytosol + STUB1@Cytosol + HSP70*@Cytosol → HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol
8. HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol → HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol + PTGES3@Cytosol
9. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@cajal body → DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus
10. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus → DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus
11. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus → degraded
12. HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol → HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol
13. HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol → degraded
14. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus → Telomerase recruitment@Nucleus
15. Telomerase recruitment@Nucleus + DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus → DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus
16. TERT@Cytosol + HSP90*|​hm2@Cytosol + PTGES3@Cytosol → HSP90*|​hm2:​PTGES3:​TERT@Cytosol
17. HSP90*|​hm2:​PTGES3:​TERT@Cytosol → HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Cytosol
18. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Cytosol → HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Nucleus
19. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@cajal body + DKC1:​GAR1:​NHP2:​NOP10:​TERC:​WRAP53@cajal body → DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@cajal body
20. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Nucleus → HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@cajal body

1. G2 phase@Nucleus → M phase@Nucleus
2. BRCA1@Nucleus → BRCA1|​ubi@Nucleus
3. FANCA@Nucleus → FANCA@Nucleus
4. RIPK1|​unfolded@Cytosol → RIPK1@Cytosol
5. HIF1A|​P564_hyd@Cytosol → HIF1A|​ubi|​P564_hyd@Cytosol
6. BIRC5@Cytosol → degraded
7. AKT*|​S473_unk|​T308_unk@Cytosol → AKT*|​S473_unk|​T308_unk|​unfolded@Cytosol
8. PI3,4,5-P3@Lipid Raft + AKT1|​T450_pho|​S473_emp|​active@Cytoplasm → AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft
9. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft → AKT1|​T450_pho|​S473_emp|​active@Cytoplasm
10. Nucleotides@Nucleus → gTelomeric G-Strand@Nucleus