Ion Fe2+ map
Fe2+@Mitochondrial intermembrane space

Identifiers
CHEBI:29033 KEGGCOMPOUND:C14818 CAS:15438-31-0

References
rc_re833( Regulated Cell Death  map ):
PMID:10561552
caracterization of human ferrochelatase as a Fe-S homodimer
PMID:16839620
review heme biosynthesis in mammals

Fe2+@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / FERROPTOSIS  map

References
rc_re2327:( Regulated Cell Death  map ) Fenton reaction

Fe2+@Endosome

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / FERROPTOSIS  map

Fe2+@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / FERROPTOSIS  map

Modifications:
In compartment: Cytosol
  1. Fe2+@Cytosol map
In compartment: Endosome
  1. Fe2+@Endosome map
In compartment: Lysosome
  1. Fe2+@Lysosome map
In compartment: Mitochondrial intermembrane space
  1. Fe2+@Mitochondrial intermembrane space map
In compartment: Nucleus
  1. Fe2+@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. Fe2+:​PHD*@Cytosol map
  2. Deferoxamine:​Fe2+@Cytosol map
  3. FTH1:​FTL:​Fe2+@Cytosol map
  4. Fe2+:​RRM1:​RRM2*@Cytosol map
In compartment: Nucleus
  1. Fe2+:​HIF1AN@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. Fe2+@Cytosol map → map Intracellular sequestering~of iron ion@Cytosol map
  2. Fe2+@Cytosol map → map Fe2+@Lysosome map
  3. Fe2+@Cytosol map → map ROS Production@Cytosol map
  4. Membrane Lipids*@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map + Fe2+@Cytosol map → map Lipid ROS@Cytosol map + Fe3+@Cytosol map + OH-@Cytosol map
  5. Fe3+@Cytosol map → map Fe2+@Endosome map
  6. Fe2+@Endosome map → map Fe2+@Cytosol map
  7. Fe2+@Cytosol map + FTH1:​FTL@Cytosol map → map FTH1:​FTL:​Fe2+@Cytosol map
  8. Fe2+@Cytosol map → map Fe3+@Extracellular space map
  9. Fe2+@Cytosol map + Deferoxamine@Cytosol map → map Deferoxamine:​Fe2+@Cytosol map
  10. Fe2+@Endosome map → map Fe2+@Cytosol map
  11. Fe2+@Cytosol map → map Fe2+@Nucleus map
  12. PHD*@Cytosol map → map Fe2+:​PHD*@Cytosol map
  13. Fe2+:​PHD*@Cytosol map + ROS@Cytosol map → map Fe3+:​PHD*@Cytosol map
  14. Fe3+:​PHD*@Cytosol map + L-ascorbate@Cytosol map → map Fe2+:​PHD*@Cytosol map
  15. RRM1@Cytosol map + RRM2*@Cytosol map + Fe2+:​RRM1:​RRM2*@Cytosol map → map Fe2+:​RRM1:​RRM2*@Cytosol map
  16. protoporphyrin IX@Mitochondrial intermembrane space map + Fe2+@Mitochondrial intermembrane space map → map ferroheme b@Mitochondrial intermembrane space map + H+@Mitochondrial intermembrane space map
  17. Fe2+@Cytosol map → map Intracellular sequestering~of iron ion@Cytosol map
  18. ferroheme b@Cytosol map + O_sub_2_endsub_@Cytosol map → map biliverdin@Cytosol map + CO@Cytosol map + Fe2+@Cytosol map
As Catalyser:
  1. purine ribonucleoside 5'-diphosphate@Cytosol map + TXN@Cytosol map → map purine 2'-deoxyribonucleoside 5'-diphosphate@Cytosol map + TXN|​-S-S-@Cytosol map
  2. pyrimidine ribonucleoside 5'-diphosphate@Cytosol map + TXN@Cytosol map → map pyrimidine 2'-deoxyribonucleoside 5'-diphosphate@Cytosol map + TXN|​-S-S-@Cytosol map
  3. H2O2@Lysosome map → map Hydroxyl radical@Lysosome map
  4. IREB2@Nucleus map → map degraded
  5. HIF1A@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map → map HIF1A|​P564_hyd@Cytosol map + succinate@Cytosol map + CO_sub_2_endsub_@Cytosol map
  6. HIF1A:​HIF1B*@Nucleus map + O_sub_2_endsub_@Nucleus map + 2-oxoglutarate@Nucleus map → map rc_s5678 + CO_sub_2_endsub_@Nucleus map + succinate@Nucleus map
  7. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map hydroxyl@Cytosol map