Simple molecule H_sub_2_endsub_O_sub_2_endsub_ map
H_sub_2_endsub_O_sub_2_endsub_@Cytosol

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map

References
PMID:15927447; PMID:19995913
Nox4, in contrast to other Nox proteins, produces large amounts of hydrogen peroxide constitutively. Known cytosolic oxidase proteins or the GTPase Rac are not required for this activity. Nox4 associates with the protein p22phox on internal membranes, where ROS generation occurs. Knockdown and gene transfection studies confirmed that Nox4 requires p22phox for ROS generation

H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space

Identifiers
CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1

References
rc_re987:( Regulated Cell Death  map ) PMID:16408030

H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix

Identifiers
CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1

References
rc_re82:( Regulated Cell Death  map ) reactionType:is.a

H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / NO_ROS_PRODUCTION  map

References
PMID:19732719
Inhibition of TGF-?? signaling??in vivo??increases CD11b+??cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide?? and H2O2 production) in neutrophils
PMID:24092389
TANs from early tumors are more cytotoxic toward tumor cells and produce higher levels of TNF-??, NO, and H2O2 and, in established tumors, these functions are downregulated and TAN acquire a more protumorigenic phenotype

Modifications:
In compartment: Cytosol
  1. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Mitochondrial Matrix
  1. H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map
In compartment: Mitochondrial intermembrane space
  1. H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. H_sub_2_endsub_O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    2. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map hydroxyl@Cytosol map
    3. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map ROS production@Cytosol map
    4. O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map H_sub_2_endsub_O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    5. H_sub_2_endsub_O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map hydroxyl@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    6. O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map
    7. H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map hydroxyl@INNATE_IMMUNE_CELL_Cytosol map
    8. H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map ROS_production@default map
    9. GSH@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map GSSG@Cytosol map
    10. Caspase9*@Mitochondrial intermembrane space map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map → map rc_s934
    11. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    12. DUSP*@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map DUSP*|​oxidized@Cytosol map
    13. H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map → map H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    14. Membrane Lipids*@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map + Fe2+@Cytosol map → map Lipid ROS@Cytosol map + Fe3+@Cytosol map + OH-@Cytosol map
    15. O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map → map O_sub_2_endsub_@Mitochondrial Matrix map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map
    16. PRDX3@Mitochondrial Matrix map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map → map PRDX3|​-SOH@Mitochondrial Matrix map
    17. PRDX3|​-SOH@Mitochondrial Matrix map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map → map PRDX3|​-SO2H@Mitochondrial Matrix map
    18. H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map → map ROS@Mitochondrial Matrix map
    19. coproporphyrinogen III@Mitochondrial intermembrane space map + O_sub_2_endsub_@Mitochondrial intermembrane space map → map protoporphyrinogen@Mitochondrial intermembrane space map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map + CO_sub_2_endsub_@Mitochondrial intermembrane space map
    20. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map hydroxyl@Cytosol map
    21. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map ROS@Cytosol map
    22. PRDX*@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map PRDX*|​-SOH@Cytosol map
    23. PRDX*|​-SOH@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map PRDX*|​-SO2H@Cytosol map
    24. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map O_sub_2_endsub_@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    25. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + O_sub_2_endsub_@Mitochondrial intermembrane space map → map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map
    26. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map → map Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space map + oxidized_cardiolipin@Mitochondrial inner membrane map
    As Catalyser:
    1. gMIF@INNATE_IMMUNE_CELL_Cytosol map → map rMIF@INNATE_IMMUNE_CELL_Cytosol map
    2. Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map