Complex Fe2+:PHD* map
Complex composition:

  1. Fe2+ map
  2. PHD* map

Fe2+:​PHD*@Cytosol

Identifiers
NAME:Fe2+:PHD*

References
rc_re391:( Regulated Cell Death  map ) reactionType:is.a
rc_re393:( Regulated Cell Death  map ) PMID:12702559
rc_re387( Regulated Cell Death  map ):
PMID:12351678
identification of PHD2 as a HIF1A prolyl hydroxylase
PMID:15652751
inhibition of HIF1A prolyl hydroxylation by succinate and fumarate
PMID:15721254
in 293 cells, OS9 interacts with HIF1 and PHD and promotes HIF1A prolylhydroxylation and degradation
rc_re392( Regulated Cell Death  map ):
PMID:15369676
inhibition of PHD by ROS
PMID:20675386
questions the hypothesis of mitochondrial derived ROS inhibiting directly PHD upon hypoxia
proposes HIF1A stabilization upon respiratory chain inhibition would rather result from enhanced oxygen availability

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. Fe2+:​PHD*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PHD*@Cytosol map → map Fe2+:​PHD*@Cytosol map
  2. Fe2+:​PHD*@Cytosol map + ROS@Cytosol map → map Fe3+:​PHD*@Cytosol map
  3. Fe3+:​PHD*@Cytosol map + L-ascorbate@Cytosol map → map Fe2+:​PHD*@Cytosol map
As Catalyser:
  1. HIF1A@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map → map HIF1A|​P564_hyd@Cytosol map + succinate@Cytosol map + CO_sub_2_endsub_@Cytosol map