Simple molecule hydroxyl map
hydroxyl@Cytosol

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map

References
PMID:15927447; PMID:19995913
Nox4, in contrast to other Nox proteins, produces large amounts of hydrogen peroxide constitutively. Known cytosolic oxidase proteins or the GTPase Rac are not required for this activity. Nox4 associates with the protein p22phox on internal membranes, where ROS generation occurs. Knockdown and gene transfection studies confirmed that Nox4 requires p22phox for ROS generation

hydroxyl@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Identifiers
CHEBI:29191, CAS:3352-57-6

hydroxyl@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / NO_ROS_PRODUCTION  map

Modifications:
In compartment: Cytosol
  1. hydroxyl@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. hydroxyl@INNATE_IMMUNE_CELL_Cytosol map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. hydroxyl@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map hydroxyl@Cytosol map
    2. hydroxyl@Cytosol map → map ROS production@Cytosol map
    3. H_sub_2_endsub_O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map hydroxyl@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    4. hydroxyl@INNATE_IMMUNE_CELL_Cytosol map → map ROS_production@default map
    5. H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map hydroxyl@INNATE_IMMUNE_CELL_Cytosol map
    6. hydroxyl@Cytosol map + DNA~integrity@Nucleus map → map DNA~damage@Nucleus map
    7. Lysosome membrane~integrity@Lysosome map + hydroxyl@Cytosol map → map LMP@Lysosome map
    8. H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map hydroxyl@Cytosol map
    9. hydroxyl@Cytosol map → map ROS@Cytosol map
    As Catalyser: