Protein TXN map

Identifiers
thioredoxin
HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / PENTOSE_PHOSPHATE_PATHWAY  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
 MACROPHAGE  map
PMID:20414655, PMID:18792398
Trx is one of the main intracellular oxido-reductases
TXN expression is upregulated in activated macrophages,
DC and probably macrophages secrete thioredoxin which reduces extracellular cystine to cysteine, which is then available for the uptake by T cells through their ASC transporter
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12655147

TXN|​-S-S-@Cytosol

Identifiers
CHEBI:18191 KEGGCOMPOUND:C00343

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / PENTOSE_PHOSPHATE_PATHWAY  map

TXN@default

References
in_re499( Innate Immunity  map ):
PMID:20414655, PMID:18792398
Trx is one of the main intracellular oxido-reductases
TXN expression is upregulated in activated macrophages,
DC and probably macrophages secrete thioredoxin which reduces extracellular cystine to cysteine, which is then available for the uptake by T cells through their ASC transporter

TXN@Cytoplasm

References
su_mpk1_mpk1_re144( Survival  map ):
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1.
PMID:12655147

Modifications:
In compartment: Cytoplasm
  1. TXN@Cytoplasm map
In compartment: Cytosol
  1. TXN|​-S-S-@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TXN@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. TXN@default map
Participates in complexes:
In compartment: Cytoplasm
  1. MAP3K5:​TXN@Cytoplasm map
In compartment: Cytosol
  1. ASK1*:​TXN@Cytosol map
  2. TXN:​TXNIP@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. TXN@INNATE_IMMUNE_CELL_Cytosol map → map TXN@default map
  2. purine ribonucleoside 5'-diphosphate@Cytosol map + TXN@Cytosol map → map purine 2'-deoxyribonucleoside 5'-diphosphate@Cytosol map + TXN|​-S-S-@Cytosol map
  3. pyrimidine ribonucleoside 5'-diphosphate@Cytosol map + TXN@Cytosol map → map pyrimidine 2'-deoxyribonucleoside 5'-diphosphate@Cytosol map + TXN|​-S-S-@Cytosol map
  4. TXN@Cytosol map + TXNIP@Cytosol map → map TXN:​TXNIP@Cytosol map
  5. TXN@Cytosol map + ASK1*@Cytosol map → map ASK1*:​TXN@Cytosol map
  6. TXN|​-S-S-@Cytosol map + NADPH@Cytosol map → map TXN@Cytosol map + NADP_super_+_endsuper_@Cytosol map
  7. PRDX*|​-S-S-@Cytosol map + TXN@Cytosol map → map PRDX*@Cytosol map + TXN|​-S-S-@Cytosol map
  8. MAP3K5:​TXN@Cytoplasm map → map MAP3K5@Cytoplasm map + TXN@Cytoplasm map
As Catalyser:
  1. Cystine@INNATE_IMMUNE_CELL_Cytosol map → map Cysteine@INNATE_IMMUNE_CELL_Cytosol map
  2. Cystine@default map → map Cysteine@default map