Protein GLUL map

Identifiers
glutamate-ammonia ligase
HUGO:GLUL HGNC:4341 ENTREZ:2752 UNIPROT:P15104

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
 RECON2  map

References
PMID:27833036
GLUL, Glutamate ammonia ligase, the key enzyme in glutamine synthesis, is upregulated in CAFs
PMID:20861672
CAF pdoduce a lot of glutamine for cancer cells.

GLUL|​unk@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re769:( Regulated Cell Death  map ) PMID:19498109

GLUL|​unk|​hm8@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

Modifications:
In compartment: Cytosol
  1. GLUL@Cytosol map
  2. GLUL|​unk@Cytosol map
  3. GLUL|​unk|​hm8@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GLUL|​unk@Cytosol map → map GLUL|​unk|​hm8@Cytosol map
  2. RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map + MLKL@Cytosol map + GLUL@Cytosol map + GLUD1@Cytosol map + PYGL@Cytosol map + PGAM5@Cytosol map → map GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map
  3. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map Glycogen breakdown@Cytosol map
  4. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map Glutaminolysis@Cytosol map
  5. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map PARP activation@Cytosol map
  6. GLUL@Cytosol map → map GLUL|​unk@Cytosol map
As Catalyser:
  1. Glutamate@Cytosol map → map glutamine@Cytosol map
  2. ATP@Mitochondrial Matrix map + ADP@Mitochondrial intermembrane space map → map ATP@Mitochondrial intermembrane space map + ADP@Mitochondrial Matrix map
  3. GLUL|​unk@Cytosol map → map GLUL|​unk|​hm8@Cytosol map
  4. Drp1*|​pho@Cytosol map → map Drp1*@Cytosol map
  5. JNK1*@Cytosol map → map JNK1*|​pho|​active@Cytosol map
  6. L-glutamate@Cytosol map + ATP@Cytosol map + NH3@Cytosol map → map L-glutamine@Cytosol map + ADP@Cytosol map