Phenotype PARP activation map
PARP activation@Cytosol

References
PMID:20823910
PMID:11907276
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.
PMID:15145826
Alkylating DNA damage stimulates a regulated form of necrotic cell death.
Cell death is determined by the effect of PARP-mediated beta-nicotinamide adenine dinucleotide (NAD) consumption on cellular metabolism

Modifications:
In compartment: Cytosol
  1. PARP activation@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map PARP activation@Cytosol map
    2. PARP activation@Cytosol map → map PARP1 overactivation@Nucleus map
    3. PARP activation@Cytosol map → map Necrosis death@Cytosol map
    As Catalyser: