GLUD1

Protein GLUD1

Identifiers
glutamate dehydrogenase 1
HUGO:GLUD1 HGNC:4335 ENTREZ:2746 UNIPROT:P00367

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / GLUTAMINE_METABOLISM
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE
RECON2

GLUD1@Mitochondrial Matrix

References
rc_re770:( Regulated Cell Death ) PMID:19498109

GLUD1|unk@Mitochondrial Matrix

References
rc_re770:( Regulated Cell Death ) PMID:19498109
rc_re761:( Regulated Cell Death ) reactionType:is.a

GLUD1@Cytosol

References
rc_re1526( Regulated Cell Death ):
PMID:22421439
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
MLKL functions downstream of RIP1 and RIP3 and is recruited to the necrosome through its interaction with RIP3
PMID:23073834
new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI
PMID:19632174
RIP3 directly interacts with glycogen phosphorylase (PYGL), glutamate ammonia ligase (GLUL), and glutamate dehydrogenase 1 (GLUD1
PMID:20823910
Molecular mechanisms of necroptosis: an ordered cellular explosion
PMID:27959630
PMID:26024392
The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis.

Modifications:
In compartment: Cytosol

GLUD1@Cytosol

In compartment: Mitochondrial Matrix

GLUD1@Mitochondrial Matrix
GLUD1|unk@Mitochondrial Matrix

Participates in complexes:
In compartment: Cytosol

GLUD1:GLUL:MLKL|S358_pho|T357_pho:PGAM5|pho:PYGL:RIPK1|S161_pho:RIPK3|S199_pho|S227_pho@Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: