Protein PYGL map

Identifiers
phosphorylase, glycogen, liver
HUGO:PYGL HGNC:9725 ENTREZ:5836 UNIPROT:P06737

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 RECON2  map

References
PMID:23010170
PMID:20823910
PYGL catalyses the breakdown of glycogen into glucose-1-phosphate (glycogenolysis), which can be converted into the glycolytic substrate glucose-6-phosphate87, thereby stimulating glycolysis (which eventually contributes to ROS generation).
PMID:23627914
Glycogen phosphorylase (GP) is the enzyme responsible for the synthesis of glucose-1-phosphate

PYGL@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map

Modifications:
In compartment: Cytosol
  1. PYGL@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map + MLKL@Cytosol map + GLUL@Cytosol map + GLUD1@Cytosol map + PYGL@Cytosol map + PGAM5@Cytosol map → map GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map
  2. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map Glycogen breakdown@Cytosol map
  3. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map Glutaminolysis@Cytosol map
  4. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map PARP activation@Cytosol map
As Catalyser:
  1. ATP@Mitochondrial Matrix map + ADP@Mitochondrial intermembrane space map → map ATP@Mitochondrial intermembrane space map + ADP@Mitochondrial Matrix map
  2. GLUL|​unk@Cytosol map → map GLUL|​unk|​hm8@Cytosol map
  3. Drp1*|​pho@Cytosol map → map Drp1*@Cytosol map
  4. JNK1*@Cytosol map → map JNK1*|​pho|​active@Cytosol map
  5. Glycogen@Cytosol map → map Glucose-1P@Cytosol map