PGAM5

Protein PGAM5

Identifiers
phosphoglycerate mutase family member 5
HUGO:PGAM5 HGNC:28763 ENTREZ:192111 UNIPROT:Q96HS1

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / GLUTAMINE_METABOLISM
Regulated Cell Death / NECROPTOSIS

References
PMID:23010170
PGAM5 promotes necroptosis through the dephosphorylation of Drp1
PMID:23073834
PMID:22265414
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.

PGAM5@Cytosol

References
PMID:26807733
Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis.
rc_re1526( Regulated Cell Death ):
PMID:22421439
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
MLKL functions downstream of RIP1 and RIP3 and is recruited to the necrosome through its interaction with RIP3
PMID:23073834
new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI
PMID:19632174
RIP3 directly interacts with glycogen phosphorylase (PYGL), glutamate ammonia ligase (GLUL), and glutamate dehydrogenase 1 (GLUD1
PMID:20823910
Molecular mechanisms of necroptosis: an ordered cellular explosion
PMID:27959630
PMID:26024392
The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis.

Modifications:
In compartment: Cytosol

PGAM5@Cytosol

Participates in complexes:
In compartment: Cytosol

GLUD1:GLUL:MLKL|S358_pho|T357_pho:PGAM5|pho:PYGL:RIPK1|S161_pho:RIPK3|S199_pho|S227_pho@Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: