GLUD1:GLUL:MLKL:PGAM5:PYGL:RIPK1:RIPK3

Complex GLUD1:GLUL:MLKL:PGAM5:PYGL:RIPK1:RIPK3

Complex composition:

Identifiers
NAME:GLUD1:GLUL:MLKL:PGAM5:PYGL:RIPK1:RIPK3

References
PMID:22421439
PMID:17603935
PMID:16469705
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
FADD:MLKL:PYGL:RIPK3:RIPK1:PGAM5:GLUL:GLUD1
PMID:23073834
New components of the necroptotic pathway.
PMID:19632174
RIP3 directly interacts with glycogen phosphorylase (PYGL), glutamate ammonia ligase (GLUL), and glutamate dehydrogenase 1 (GLUD1)
PMID:26807733
Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis.
rc_re1526( Regulated Cell Death ):
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
MLKL functions downstream of RIP1 and RIP3 and is recruited to the necrosome through its interaction with RIP3
new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI
PMID:20823910
Molecular mechanisms of necroptosis: an ordered cellular explosion
PMID:27959630
PMID:26024392
The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis.
rc_re1529( Regulated Cell Death ):
PGAM5L/PGAM5S activate the mitochondrial fission regulator Drp1 by dephosphorylation, thus leading to mitochondrial fission.
PMID:22265414
PGAM5S recruited the mitochondrial fission factor Drp1 and activated its GTPase activity by dephosphorylating the serine 637 site of Drp1
rc_re1536:( Regulated Cell Death ) PMID:19037093

Modifications:
Participates in complexes:
In compartment: Cytosol

GLUD1:GLUL:MLKL|S358_pho|T357_pho:PGAM5|pho:PYGL:RIPK1|S161_pho:RIPK3|S199_pho|S227_pho@Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: