Protein Caspase3_sub_TRUNC_endsub_* map

Identifiers
caspase 3 apoptosis-related cysteine peptidase
"caspase 3 apoptosis-related cysteine protease"
HUGO:CASPASE3 HGNC:1504 ENTREZ:836 UNIPROT:P42574
HUGO:CASPASE3 GENECARDS:CASPASE3 WIKI:CASPASE3 HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3
HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / WNT_NON_CANONICAL  map

References
CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented.
PMID:17613518

Caspase3_sub_TRUNC_endsub_*@Cytoplasm

References
su_mpk1_mpk1_re34( Survival  map ):
Activated caspase-9 cleaves and activates caspase-3 leading to apoptosis.
PMID:9390557
su_mpk1_mpk1_re30( Survival  map ):
KSR1 is cleaved by CASPASE3 in two regions: the C-ter region which mediates MEK binding and the N-ter region which contains the ERK binding site and the C1 domain required for plasma membrane localisation
PMID:17613518
su_wnc1_s_wnc2_re70( Survival  map ):
Only NFAT1 is sensitive to cleavage by caspase-3 at consensus sites: DELD and/or DVLD.
PMID:16455648
su_wnc1_s_wnc4_re40:( Survival  map ) PMID:19900451

Modifications:
In compartment: Cytoplasm
  1. Caspase3_sub_TRUNC_endsub_*@Cytoplasm map
  2. Caspase3_sub_TRUNC_endsub_*@Cytoplasm map
  3. Caspase3_sub_TRUNC_endsub_*@Cytoplasm map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Caspase3_sub_TRUNC_endsub_*@Cytoplasm map → map Apoptosis@Cytoplasm map
    2. Caspase3*@Cytoplasm map → map Caspase3_sub_TRUNC_endsub_*@Cytoplasm map
    3. Apoptosis@Cytoplasm map → map Caspase3_sub_TRUNC_endsub_*@Cytoplasm map
    As Catalyser:
    1. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map → map BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1-CTER*:​MEK*@Cytoplasm map
    2. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map → map NFAT1*@Cytoplasm map
    3. APC@Cytoplasm map → map APC_sub_TRUNC_endsub_*@Cytoplasm map