Protein BBC3 map

Identifiers
BCL2 binding component 3
HUGO:BBC3, HGNC:17868, ENTREZ:27113, UNIPROT:Q96PG8, GENECARDS:GC19M047724
HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / MITOCHONDRIA_OXIDATIVE_STRESS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / ER_STRESS  map

References
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain???containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1???dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
PMID:23430059
synonym:PUMA

BBC3@Mitochondria

References
em_emtc_emtc_re425( EMT Senescence  map ):
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain???containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1???dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
em_emtc_emtc_re428( EMT Senescence  map ):
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
It is via this binding to BBC3 (an apoptic inducer) that BCL2L1 exhibits its anti-apoptotic effect.
em_emtc_emtc_re436( EMT Senescence  map ):
It is via this binding to BBC3 (an apoptic inducer) that BCL2 and BCL2L1 exhibit their anti-apoptic effect.

BBC3@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

BBC3@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re593:( Regulated Cell Death  map ) PMID:16608847

BBC3@Endopasmic Reticulum

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

Modifications:
In compartment: Cytosol
  1. BBC3@Cytosol map
In compartment: Endopasmic Reticulum
  1. BBC3@Endopasmic Reticulum map
In compartment: Mitochondria
  1. BBC3@Mitochondria map
In compartment: Mitochondrial inner membrane
  1. BBC3@Mitochondrial inner membrane map
Participates in complexes:
In compartment: Endopasmic Reticulum
  1. BBC3:​IRE1-alpha*@Endopasmic Reticulum map
In compartment: Mitochondria
  1. BBC3:​BCL2@Mitochondria map
  2. BBC3:​BCL2-XL*@Mitochondria map
In compartment: Mitochondrial inner membrane
  1. BBC3:​BCL2@Mitochondrial inner membrane map
  2. BBC3:​BCL2A1@Mitochondrial inner membrane map
  3. BBC3:​BCL2L2@Mitochondrial inner membrane map
  4. BBC3:​BCL2-XL*@Mitochondrial inner membrane map
  5. BBC3:​MCL1|​S159_unk@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. BBC3@Mitochondria map + BCL2-XL*@Mitochondria map → map BBC3:​BCL2-XL*@Mitochondria map
  2. BBC3@Mitochondria map → map Apoptosis@Cytosol map
  3. BBC3@Mitochondria map + BCL2@Mitochondria map → map BBC3:​BCL2@Mitochondria map
  4. IRE1-alpha*@Endopasmic Reticulum map + BBC3@Endopasmic Reticulum map → map BBC3:​IRE1-alpha*@Endopasmic Reticulum map
  5. rBBC3@Nucleus map → map BBC3@Cytosol map
  6. BBC3@Mitochondrial inner membrane map + BCL2|​pho@Mitochondrial inner membrane map → map BBC3:​BCL2@Mitochondrial inner membrane map
  7. BBC3@Mitochondrial inner membrane map + BCL2-XL*@Mitochondrial inner membrane map → map BBC3:​BCL2-XL*@Mitochondrial inner membrane map
  8. BBC3@Mitochondrial inner membrane map + BCL2L2@Mitochondrial inner membrane map → map BBC3:​BCL2L2@Mitochondrial inner membrane map
  9. BBC3@Mitochondrial inner membrane map + BCL2A1@Mitochondrial inner membrane map → map BBC3:​BCL2A1@Mitochondrial inner membrane map
  10. BBC3@Mitochondrial inner membrane map + MCL1|​S159_unk@Mitochondrial inner membrane map → map BBC3:​MCL1|​S159_unk@Mitochondrial inner membrane map
As Catalyser:
  1. ruXBP1@Nucleus map → map rsXBP1@Nucleus map