Identifiers
transducin-like enhancer of split 1 (E(sp1) homolog Drosophila)
"transducin-like enhancer of split 1 homolog of Drosophila E(sp1)"
HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1
transducin-like enhancer of split 2 (E(sp1) homolog Drosophila)
HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2
transducin-like enhancer of split 3 (E(sp1) homolog Drosophila)
HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3
transducin-like enhancer of split 4 (E(sp1) homolog Drosophila)
HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4
amino-terminal enhancer of split
GRG5 TLE5
HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES
transducin-like enhancer of split 6 (E(sp1) homolog Drosophila)
HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

References
References_begin
non-DNA binding transcription factor
PMID:20925119
References-end

References
s_wca3_re35( Survival  ):
CK2 phosphorylates TLE
PMID:15367661
s_wca3_re39( Survival  ):
Its suggested that XIAP constitutively ubiquitinate TLE
PMID:22304967
s_wca3_re111:( Survival  ) PMID:16510874
s_wca3_re135:( Survival  ) PMID:12050133 PPMID:12441302
s_wca3_re138:( Survival  ) PMID:20925119

References
s_wca3_re35( Survival  ):
CK2 phosphorylates TLE
PMID:15367661

References
s_wca3_re39( Survival  ):
Its suggested that XIAP constitutively ubiquitinate TLE
PMID:22304967

1. TLE*@Nucleus
2. TLE*|​ubi@Nucleus
3. TLE*|​S239_pho@Nucleus

1. AES:​TLE*@Nucleus
2. SIX3:​TLE*@Nucleus
3. HDAC1_2*:​TLE*|​ubi@Nucleus
4. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus
5. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus
6. HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus

1. CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus + TLE*@Nucleus → CTBP*@Nucleus + HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus
2. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus → BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus
3. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus → BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus
4. SIX3@Nucleus + TLE*@Nucleus → SIX3:​TLE*@Nucleus
5. TLE*@Nucleus + AES@Nucleus → AES:​TLE*@Nucleus
6. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus → HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus
7. HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus + LEF_TCF*@Nucleus → HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus + LEF_TCF*|​pho@Nucleus
8. LEF_TCF*@Nucleus + HDAC1_2*@Nucleus + TLE*@Nucleus + gWRE*@Nucleus → HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus
9. TLE*@Nucleus → TLE*|​S239_pho@Nucleus
10. HES1@Nucleus + TLE*|​S239_pho@Nucleus → su_wca1_s_wca3_s195
11. TLE*@Nucleus → TLE*|​ubi@Nucleus
12. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus → HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus
13. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus

1. gGenes under control of _br_CBP-mediated transcription*@Nucleus → rRNA@Nucleus
2. gWNT1@Nucleus → rWNT1@Nucleus
3. gGene under control of_br_ P300-mediated transcription*@Nucleus → rRNA@Nucleus