Protein cleaved~GSPT1* map

Identifiers
G1 to S phase transition 1
HUGO:GSPT1 HGNC:4621 ENTREZ:2935 UNIPROT:P15170

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map

cleaved~GSPT1*@Cytosol

References
rc_re674( Regulated Cell Death  map ):
PMID:12865429
in HEK293 expressing full length GSPT1-FLAG, 10 to 20% of the protein is cleaved
in HEK293, mass spectrometry identification of GSPT1 cleaved at position 70 after purification of BIR3 domain binding proteins
rc_re675( Regulated Cell Death  map ):
cleaved GSPT1 harbors a IAP binding motif at tis C-terminal, AKPF, related to those found in DIABLO or HTRA2
in vitro, cleaved GSPT1 and XIAP interact
in HEK293, interaction between endogenous proteins
in HEK293 cytoplasmic extract (S100 fraction), cleaved GSPT1 increases CYCS+ATP induced cleavage of CASP3

Modifications:
In compartment: Cytosol
  1. cleaved~GSPT1*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. XIAP|​S87_unk:​cleaved~GSPT1*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GSPT1@Cytosol map → map cleaved~GSPT1*@Cytosol map
  2. XIAP|​S87_unk@Cytosol map + cleaved~GSPT1*@Cytosol map → map XIAP|​S87_unk:​cleaved~GSPT1*@Cytosol map
As Catalyser: