Complex CAPN2:Ca2+_
Complex composition:
- CAPN2
- Ca2+_
CAPN2:Ca2+_@Cytosol
Identifiers
NAME:CAPN2:Ca2+_
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death
/ APOPTOSIS
Regulated Cell Death
/ CASPASES
Regulated Cell Death
/ DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death
/ MOMP_REGULATION
References
rc_re1668:( Regulated Cell Death
) PMID:21887410
rc_re1840( Regulated Cell Death
):
PMID:23242420
Calcium induced calpain-mediated Bax and Atg5 cleavage resulted in the collapse of the mitochondrial membrane potential and cytochrome c release
Modifications:
Participates in complexes:
In compartment: Cytosol
- CAPN2:Ca2+_@Cytosol
Participates in reactions:
As Reactant or Product:- XIAP|S87_unk@Cytosol
→
CAPN2:Ca2+_@Cytosol
As Catalyser:- BAX@Cytosol
→
cleaved BAX*@Cytosol
- VDAC*@Mitochondria
→
degraded
- p53*|S15_unk@Cytosol
→
degraded
- BAX|S163_unk|T167_unk@Mitochondrial inner membrane
→
cleaved BAX*@Mitochondrial inner membrane
- Caspase9*|S196_unk|T125_unk|S144_unk|Y153_unk@Cytosol
→
degraded
- BID|unk@Cytosol
→
cleaved_BID*@Cytosol
- XIAP|ubi@Cytosol
→
degraded