Protein DIABLO map

Identifiers
diablo, IAP-binding mitochondrial protein
HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

DIABLO@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re2( Regulated Cell Death  map ):
hierarchical:post-MOMP
PMID:14532003
PMID:10929711
PMID:12660240
in Hela upn taxol treatment
rc_re657:( Regulated Cell Death  map ) PMID:15300255
rc_re736( Regulated Cell Death  map ):
identification of DIABLO as an inhibitor of XIAP
PMID:11140637
structure of XIAP BIR3 complexed to a peptide from DIABLO
PMID:15078891
DIABLO inhibits XIAP ubiquitin-ligase activity
rc_re737( Regulated Cell Death  map ):
in Hela, upon taxol treatment, interaction detected by GST pull-down, BIRC5 antagonizes DIABLO pro-apoptotic effect
rc_re738( Regulated Cell Death  map ):
PMID:11801603
in 293T, interaction between ectopically expressed proteins
in vitro, interaction between a DIABLO peptide and the BIR domain of ML-IAP
in 293T, binding of DIABLO to BIRC7 antagonizes the binding of processed CASP9
rc_re1160( Regulated Cell Death  map ):
PMID:18022362
SMAC mimetic induces cIAP auto-ubiquitinylation and degradation
PMID:18022363

DIABLO@Mitochondrial intermembrane space

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re2( Regulated Cell Death  map ):
hierarchical:post-MOMP
PMID:14532003
PMID:10929711
PMID:12660240
in Hela upn taxol treatment

DIABLO|​ubi@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re657:( Regulated Cell Death  map ) PMID:15300255

Modifications:
In compartment: Cytosol
  1. DIABLO@Cytosol map
  2. DIABLO|​ubi@Cytosol map
In compartment: Mitochondrial intermembrane space
  1. DIABLO@Mitochondrial intermembrane space map
Participates in complexes:
In compartment: Cytosol
  1. BIRC7:​DIABLO@Cytosol map
  2. DIABLO:​XIAP|​S87_unk@Cytosol map
  3. BIRC5|​T34_pho:​DIABLO@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. DIABLO@Mitochondrial intermembrane space map → map DIABLO@Cytosol map
  2. DIABLO@Cytosol map → map DIABLO|​ubi@Cytosol map
  3. DIABLO|​ubi@Cytosol map → map degraded
  4. XIAP|​S87_unk@Cytosol map + DIABLO@Cytosol map → map DIABLO:​XIAP|​S87_unk@Cytosol map
  5. BIRC5|​T34_pho@Cytosol map + DIABLO@Cytosol map → map BIRC5|​T34_pho:​DIABLO@Cytosol map
  6. DIABLO@Cytosol map + BIRC7@Cytosol map → map BIRC7:​DIABLO@Cytosol map
As Catalyser:
  1. cIAP*@TNFRSF1 Receptor Complex map → map cIAP*|​ubi@TNFRSF1 Receptor Complex map