Identifiers
XIAP associated factor 1
HUGO:XAF1 HGNC:30932 ENTREZ:54739 UNIPROT:Q6GPH4

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

References
PMID:23070005

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

References
rc_re666( Regulated Cell Death  ):
PMID:11175744
in vitro, Y2H
in vitro, GST pulldown
in transfected Hela cells, coIP
in Hela cells expressing fluorescent proein fusions, XAF1 is nuclear and its co-expression with XIAP induces XIAP nuclear retention
in vitro, XIAP mediated inhibition of CASP3 activity is blocked by XAF1
in HEL-299 human embryonic lung cells, XAF1 expression reverts the protective effect of XIAP expression toward serum deprivation-induced cell death

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

1. XAF1@Cytosol

1. XAF1@Nucleus

1. XAF1@TNFRSF1 Receptor Complex

1. XAF1:​XIAP@Cytosol

1. XAF1:​XIAP|​S87_unk@Nucleus

1. XAF1:​cIAP*@TNFRSF1 Receptor Complex

1. cIAP*@TNFRSF1 Receptor Complex + XAF1@TNFRSF1 Receptor Complex → XAF1:​cIAP*@TNFRSF1 Receptor Complex
2. XAF1@Cytosol + XIAP@Cytosol → XAF1:​XIAP@Cytosol
3. XIAP|​S87_unk@Cytosol + XAF1@Nucleus → XAF1:​XIAP|​S87_unk@Nucleus