Complex CD14:IRAK2:IRAK4:LY96:MYD88:TIRAP:TLR2/4* map
Complex composition:

  1. CD14 map
  2. IRAK4 map
  3. TLR2/4* map
  4. LY96 map
  5. MYD88 map
  6. TIRAP map
  7. IRAK2 map

CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane

Identifiers
NAME:CD14:HMGB1:IRAK2:IRAK4:LY96:MYD88:TIRAP:TLR2/4*

Maps_Modules
MODEULE:MACROPHAGE
MODEULE:MDSC

References
PMID:14660645, PMID:16878026, PMID:23681101
The adaptor proteins MyD88 and TIRAP associate with TLR 2 and TLR 4 after receptor engagement.
Transfection of dominant negative MyD88 or TIRAP inhibited almost all of the HMGB1- and LPS-induced NF-??B activation.
MyD88 recruits members of the death domain-containing serine/threonine IL-1R-associated kinase (IRAK) family.
PMID:12620219
MyD88 mediates a close interaction of the two related IRAK molecules,
which is essential to allow IRAK-4 to phosphorylate IRAK-1. Phosphorylation of IRAK-1
reduces its affinity for MyD88, while increasing its affinity for TRAF6

Modifications:
Participates in complexes:
In compartment: Membrane
  1. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IRAK2@Cytosol map + IRAK4@Cytosol map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
As Catalyser:
  1. gTGFB1@Cytosol map → map rTGFB1@Cytosol map
  2. gIL10@Cytosol map → map rIL10@Cytosol map
  3. IL10@Cytosol map → map IL10@default map
  4. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
  5. IRAK1@Cytosol map → map IRAK1|​pho|​active@Cytosol map
  6. rCXCL2@Cytosol map → map CXCL2@Cytosol map
  7. ERK*@Cytosol map → map ERK*|​pho|​active@Cytosol map
  8. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  9. PIP3*@Cytosol map → map PIP2*@Cytosol map
  10. gIL6@Cytosol map → map rIL6@Cytosol map
  11. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map
  12. Caspase1*:​NLRP3:​PYCARD@Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol map