Protein IL10 map

Identifiers
HUGO:IL10

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:21115385
IL10 is immunosuppressive cytokine.
PMID:10623821, PMID:10623821
IL10??? ??? expression in macrophages is assosiated
with TAM (M2) phenotype.
PMID:10542212
IL10??? ??? promotes M2??? ???phenotype of macrophages
trough suppression of??? ???NFkB signaling
and inhibition of synthesis of pro-inflammatory cytokines.
PMID:11875494
IL10 stimulates HO1 expression via MAPK p38 stimulation.
PMID: PMID:16713974, PMID:14607900
IL10 and Stat3 mediate feedback inhibition of TLR signaling. TLR2/TLR4 induces
IL10 expression. IL10 inhibits exppression of TNF downstream of TLR.
PMID:PMID:16713974
Production of IL10 is partially ERK dependent.

IL10@Cytosol

Identifiers

Maps_Modules

References

IL10@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. IL10@Cytosol map
In compartment: default
  1. IL10@default map
Participates in complexes:
In compartment: Membrane
  1. IL10:​IL10RA:​IL10RB@Membrane map
  2. IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  3. IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL10@default map + IL10RA:​IL10RB@Membrane map → map IL10:​IL10RA:​IL10RB@Membrane map
  2. IL10:​IL10RA:​IL10RB@Membrane map + JAK1@Membrane map + TYK2@Membrane map → map IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  3. IL10:​IL10RA:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map → map IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@Membrane map
  4. rIL10@Cytosol map → map IL10@Cytosol map
  5. IL10@Cytosol map → map IL10@default map
As Catalyser:
  1. gARG2@Cytosol map → map rARG2@Cytosol map
  2. gMHC class II*@Cytosol map → map rMHC class II*@Cytosol map
  3. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  4. gCD163@Cytosol map → map rCD163@Cytosol map
  5. rCD80@Cytosol map → map CD80@Membrane map
  6. gTNIP3@Cytosol map → map rTNIP3@Cytosol map
  7. NFKB1_p50*:​NFKBIA:​RELA@Cytosol map → map NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map
  8. rICAM1@Cytosol map → map ICAM1@Membrane map
  9. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map
  10. gNFKBID@Cytosol map → map rNFKBID@Cytosol map