Protein TIRAP map

Identifiers
HUGO:TIRAP

Maps_Modules
MODULE:MACROPHAGE
MODEULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:14660645, PMID:16878026, PMID:23681101
The adaptor proteins MyD88 and TIRAP associate with TLR 2 and TLR 4 after receptor engagement.

TIRAP@Membrane

Identifiers

Maps_Modules

References

Modifications:
In compartment: Membrane
  1. TIRAP@Membrane map
Participates in complexes:
In compartment: Membrane
  1. CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
  2. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
Participates in reactions:
As Reactant or Product:
  1. TLR2/4*@Membrane map + LY96@Membrane map + TIRAP@Membrane map + MYD88@Membrane map + CD14@Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
  2. IRAK2@Cytosol map + IRAK4@Cytosol map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
As Catalyser:
  1. gTGFB1@Cytosol map → map rTGFB1@Cytosol map
  2. gIL10@Cytosol map → map rIL10@Cytosol map
  3. IL10@Cytosol map → map IL10@default map
  4. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
  5. IRAK1@Cytosol map → map IRAK1|​pho|​active@Cytosol map
  6. rCXCL2@Cytosol map → map CXCL2@Cytosol map
  7. ERK*@Cytosol map → map ERK*|​pho|​active@Cytosol map
  8. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  9. PIP3*@Cytosol map → map PIP2*@Cytosol map
  10. gIL6@Cytosol map → map rIL6@Cytosol map
  11. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map
  12. Caspase1*:​NLRP3:​PYCARD@Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol map