Protein IRAK4 map

Identifiers
HUGO:IRAK4

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:12620219
MyD88 mediates a close interaction of the two related IRAK molecules,
which is essential to allow IRAK-4 to phosphorylate IRAK-1. Phosphorylation of IRAK-1
reduces its affinity for MyD88, while increasing its affinity for TRAF6

IRAK4@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. IRAK4@Cytosol map
Participates in complexes:
In compartment: Membrane
  1. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IRAK2@Cytosol map + IRAK4@Cytosol map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
As Catalyser:
  1. gTGFB1@Cytosol map → map rTGFB1@Cytosol map
  2. gIL10@Cytosol map → map rIL10@Cytosol map
  3. IL10@Cytosol map → map IL10@default map
  4. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
  5. IRAK1@Cytosol map → map IRAK1|​pho|​active@Cytosol map
  6. rCXCL2@Cytosol map → map CXCL2@Cytosol map
  7. ERK*@Cytosol map → map ERK*|​pho|​active@Cytosol map
  8. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  9. PIP3*@Cytosol map → map PIP2*@Cytosol map
  10. gIL6@Cytosol map → map rIL6@Cytosol map
  11. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map
  12. Caspase1*:​NLRP3:​PYCARD@Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol map