Complex NLRP3:PYCARD:cleaved Caspase1* map
Complex composition:

  1. cleaved Caspase1* map
  2. NLRP3 map
  3. PYCARD map

(NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol
MODULE:MACROPHAGE
MODULE:MDSC
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3)
PMID:20385749
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
PMID: 23202296
(Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1?? (IL-1??), which curtails anticancer immunity.
Modifications:
Participates in complexes:
In compartment: Cytosol
  1. (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Caspase1*:​NLRP3:​PYCARD@Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol map
As Catalyser:
  1. IL1B@Cytosol map → map trILB1@Cytosol map