Identifiers
HUGO:FOS
FBJ murine osteosarcoma viral oncogene homolog
HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100
Fos proto-oncogene, AP-1 transcription factor subunit
HUGO:FOS hgnc_id:HGNC:3796 HGNC:3796 ENTREZ:2353 UNIPROT:P01100
"v-fos FBJ murine osteosarcoma viral oncogene homolog"
HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
EMT Senescence / SENESCENCE
HMC:ENABLING_REPLICATION_AND_IMMORTALITY
Telomere Maintenance / TELOMERASE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ER_STRESS
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / MIRNA_TF_IMMUNOSUPPRESSIVE
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_NON_CANONICAL
References
PMID:23430059
PMID:21385848, PMID:22634314
c-Fos downregulates mRNA expression of TNF, IL6, IL1B, IL12p40. IL12p35, IL23a
Additionally Fos downregulates CD86, CD40 surface expression, IL2 secretion and Tcell activation.
PMID:22634314
Expression of IL-10 was enhanced in DC overexpressed Fos.
PMID:16394015 PMID:19667062
TPL-2 ERK pathway induces Fos expression in macrophages ()
PMID:16394015 , PMID:19667062, PMID:15067049
Fos inhibits the expression of IL-12 p40 and IFNB and upregulates IL10 production downstream of FOS in macrophages and DCs
PMID:9064320
CD16-induced ERK activation provides TNFA expression in NK cells.
MEK/ERK cascade induces AP1(c-fos) phosphorylation downstream of CD16
c-FOS is activated by ERK and RSK through phosphorylation.
PMID:16393692
References
mo_re97:( motility ) PMID:23418787
mo_re296:( motility ) PMID:29556339
References
mo_re296:( motility ) PMID:29556339
mo_re51:( motility ) PMID:23589069 PMID:22131018 PMID:29556339
References
in_re869( Innate Immunity ):
PMID:16327802
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
References
in_re869( Innate Immunity ):
PMID:16327802
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
in_re423( Innate Immunity ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.
in_re558( Innate Immunity ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:16413922
NFKBID (IkBNS) inhibit late phase (after 3h) of expression of proinflanotory cytokines
Il-12p40 (IL-12p40), Il-18 (IL-18) and Csf3 (G_CSF).
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:23390297
MIF inhitits expression of M1 markers such as IL12p40
in_re1364( Innate Immunity ):
IL13 and TNF together (but neither IL-13 nor TNF alone) upregulates TGFB1 expression downstream of IL13RA2.
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages via TLR4-dependent mechanisms.
References
su_mpk1_mpk1_re177( Survival ):
Phosphorylation by both ERKs and their downstream RSKs can stabilise the c-FOS protein for several hours. The combination of these phosphorylations allows c-FOS sustained activity.
PMID:16393692
su_mpk1_mpk1_re175( Survival ):
AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers.
PMID:11274345
→ FOS|pho|active@Cytosol
→ FOS|pho|active@Nucleus
→ FOS@Cytosol
→ FOS|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ FOS@INNATE_IMMUNE_CELL_Cytosol
→ FOS|pho|active@Nucleus
→ FOS@Nucleus
→ AP-1*@Cytosol
+ FOS|pho@Nucleus → su_mpk1_mpk1_s1052
→ FOS|pho@Nucleus
→ FOS@Nucleus
→ FOS@Nucleus
+ gAP-1_ARRE binding sites*@Nucleus + JUN@Nucleus + FOS@Nucleus → AP-1_ARRE binding sites*:NFAT*@Nucleus + CNA*:CNB*@Nucleus + ERK2*@Nucleus + MEK1*@Nucleus
+ JUN@Nucleus + FOS@Nucleus + NFAT*@Nucleus → AP-1_ARRE binding sites*:NFAT*@Nucleus
→ rEndothelin1*@Nucleus
→ rTGFB1@INNATE_IMMUNE_CELL_Cytosol
→ rIL10@INNATE_IMMUNE_CELL_Cytosol
→ rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→ rINFB*@INNATE_IMMUNE_CELL_Cytosol
→ rMMP7@Nucleus
→ rITGA2@Nucleus
→ rTERT@Nucleus