Reaction state_transition su_wnc1_s_wnc3_re31
CNA*:CNB*:ERK2*:MEK1*:NFAT*|pho@Nucleus
+ gAP-1_ARRE binding sites*@Nucleus
+ JUN@Nucleus
+ FOS@Nucleus
→ AP-1_ARRE binding sites*:NFAT*@Nucleus
+ CNA*:CNB*@Nucleus
+ ERK2*@Nucleus
+ MEK1*@Nucleus
Reaction regulators:
- Catalysis
- CNA*:CNB*:ERK2*:MEK1*:NFAT*|pho@Nucleus
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_NON_CANONICAL
References
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs