Complex KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*
Complex composition:
- PPP3CB_sub_trunc_endsub_*
- PPP3R*
- NFAT*
- Tubulin-_alpha_*
- KPNB1
- TNPO1
KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
Identifiers
NAME:KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_NON_CANONICAL
References
Constitutively active
PMID:17662023, PMID:17593948, PMID:14627704
s_wnc2_re45( Survival
):
Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT.
PMID:21278340
TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex
PMID:21709260
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
Participates in reactions:
As Reactant or Product:- KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
→
KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:Tubulin-_alpha_*@Nucleus
- (NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*)|active@Cytoplasm
+ KPNB1@Cytoplasm
+ Tubulin-_alpha_*@Cytoplasm
+ TNPO1@Cytoplasm
→
KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
- KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
+ LRRK2@Cytoplasm
+ CSE1L@Cytoplasm
+ rNRON@Cytoplasm
→
CSE1L:KPNB1:LRRK2:NFAT*:NRON:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
As Catalyser: