Identifiers
HUGO:MAPK1 HGNC:6871
mitogen-activated protein kinase 1
HUGO:MAPK1, HGNC:6871, ENTREZ:5594, GENECARDS:GC22M022108, UNIPROT:P28482
HUGO:MAPK1, HGNC:6871, ENTREZ:5594, UNIPROT:P28482
PRKM1, PRKM2
HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL
References
PMID:16076871 PMID:11335727
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK2 (phosphorylated) may encounter monomeric, inactive ERK2.
ERK2 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK2 phosphorylates the critical Tyr and Thr on ERK2, converting two ATP to ADP. Phosphorylation of ERK-2 activates its kinase activity.
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
PMID:21196257, PMID:21196179
References
em_emtc_emtc_re391( EMT Senescence ):
PMID:8388392
PMID:8226933
In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1.
ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
MEK1 phosphorylates the critical Tyr and Thr on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.
em_emtc_emtc_re395( EMT Senescence ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
References
em_emtc_emtc_re395( EMT Senescence ):
PMID:9604935
Phosphorylation of ERK-1/2 promotes its homodimerization
PMID:18775330
Scaffolds and ERK dimers are essential for the activation of cytoplasmic but not nuclear substrates.
Dimerization is critical for connecting the scaffolded ERK complex to cognate cytoplasmic substrates.
Contrarily, nuclear substrates associate to ERK monomers.
em_emtc_emtc_re383( EMT Senescence ):
Negative feedback: MAPK1/ERK2 phosphorylates RAF1 on Ser 29, 43, 289, 296, 301, 642, generating an inactive kinase.
PIN1, a prolyl isomerase converts pSer and pThr residues from the cis to the trans conformation, which is preferentially recognized and dephosphorylated by PPP2R1A.
em_emtc_emtc_re397( EMT Senescence ):
PMID:9155017
Mnk1 and Mnk2 bind to Erk1, Erk2 and p38 but not JNK
Mnk1 and Mnk2 are in vitro substrates of Erk2 and p38
Mnk1 is a MAP kinase-activated eIF-4E kinase
References
ce_re376:( Cell Cycle DNA Repair ) PMID:18083840
References
s_wnc4_re34( Survival ):
Unknown which amino acid residue
PMID:22399895
→ ERK2*|pho@Cytosol
→ Lymphangiogenesis@Cytosol
→ ERK2*|T_pho|Y_pho|active@Cytosol
→ ERK2*|T_pho|Y_pho|active@Cytosol
→ ERK2*|T_pho|Y_pho|hm2|active@Cytosol
+ ERK2*@Nucleus + MEK1*@Nucleus → CNA*:CNB*:ERK2*:MEK1*:NFAT*@Nucleus
→ CNA*:CNB*:ERK2*:MEK1*:NFAT*|pho@Nucleus
+ gAP-1_ARRE binding sites*@Nucleus + JUN@Nucleus + FOS@Nucleus → AP-1_ARRE binding sites*:NFAT*@Nucleus + CNA*:CNB*@Nucleus + ERK2*@Nucleus + MEK1*@Nucleus
→ ERK2*@Nucleus
→ MAPK pathway@Cytoplasm
→ MPS1*|T676_pho@Nucleus
+ ATP@Cytosol → RAF1|S_pho|closed@Cytosol + ADP@Cytosol
+ ATP@Cytosol → MKNK2|pho@Cytosol + ADP@Cytosol
+ gAP-1_ARRE binding sites*@Nucleus + JUN@Nucleus + FOS@Nucleus → AP-1_ARRE binding sites*:NFAT*@Nucleus + CNA*:CNB*@Nucleus + ERK2*@Nucleus + MEK1*@Nucleus
→ APC|pho@Cytoplasm