Protein BLM map

Identifiers
Blomm syndrome, RecQ helicase-like
HUGO:BLM
Bloom syndrome, RecQ helicase-like
HUGO:BLM, HGNC:1058, ENTREZ:641, UNIPROT:P54132

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / HR  map
 Cell Cycle DNA Repair  map  / FANCONI  map
 Cell Cycle DNA Repair  map  / TLS  map

References
For HR pathway, PMID:22657828
PMID:19772495, PMID:16697054, PMID:19847258
For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676
FA core complex regulates REV1 and activated TLS
PMID:22266823
BLM in telomere maintenance
PMID:23253856
Resolving stalled replication fork
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737

Modifications:
In compartment: Nucleus
  1. BLM@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. BLM:​EXO1@Nucleus map
  2. BLM:​RMI1:​TOP3A@Nucleus map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map
  4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. EXO1@Nucleus map + BLM@Nucleus map → map BLM:​EXO1@Nucleus map
  2. TOP3A@Nucleus map + BLM@Nucleus map + RMI1@Nucleus map → map BLM:​RMI1:​TOP3A@Nucleus map
  3. FANCA|​pho:​FANCG|​S7_pho@Nucleus map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@Nucleus map + FAAP24*:​FANCM@Nucleus map + FAAP100*:​FANCB:​FANCL@Nucleus map + BLM@Nucleus map + HES1@Nucleus map + FAAP20*@Nucleus map → map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map
  4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map + TOP3A@Nucleus map + RPA1:​RPA2:​RPA3@Nucleus map → map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus map
  5. BLM@Nucleus map → map Telomere maintenance@Nucleus map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  3. gHR_DNA_st5*@Nucleus map → map gHR_DNA_st6*@Nucleus map
  4. gFanconi_DNA_st2*@Nucleus map → map gFanconi_DNA_st3*@Nucleus map
  5. FANCD2|​pho@Nucleus map → map FANCD2|​K561_ubi|​pho@Nucleus map
  6. FANCI|​pho@Nucleus map → map FANCI|​K523_ubi|​pho@Nucleus map
  7. gFanconi_DNA_st4*@Nucleus map → map gFanconi_DNA_st5*@Nucleus map
  8. FANCD2@Nucleus map → map FANCD2|​pho@Nucleus map
  9. FANCD2|​K561_ubi|​pho@Nucleus map + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  10. PCNA@Nucleus map + FEN1@Nucleus map + WRN@Nucleus map → map FEN1:​PCNA:​WRN@Nucleus map
  11. gTLS_DNA_st1*@Nucleus map → map gTLS_DNA_st2*@Nucleus map
  12. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Uncoiled_telomeric_DNA*@Nucleus map