Identifiers
poly (ADP-ribose) polymerase 3
HUGO:PARP3, HGNC:273, ENTREZ:10039, UNIPROT:Q9Y6F1

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / HR 
 Cell Cycle DNA Repair   / C_NHEJ 

References
PMID:22055391
PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1
PMID:21270334
PARPs in cellular functions (PARP3 in telomere maintenance)
PMID:22713970, PMID:21270334
PARP3 in HR and C_NHEJ
PMID:22469522, PMID:196269035
PARP3 in chromatin remodeling
PMID:22469522, PMID:22713970
APLF and PARP3 in C_NHEJ
PMID:21211721???
PMID:23178593
PMID:18077224???
PARP3 in C_NHEJ
PMID:22743550

References
ce_re95:( Cell Cycle DNA Repair  ) PMID:11955432, PMID:19772495

1. PARP3@Nucleus

1. PARP1|​PolyADPribose_unk|​pho:​PARP3@Nucleus
2. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus
3. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus

1. PARP3@Nucleus → Telomere maintenance@Nucleus
2. PARP3@Nucleus + PARP1|​PolyADPribose_unk|​pho@Nucleus → PARP1|​PolyADPribose_unk|​pho:​PARP3@Nucleus
3. PARP3@Nucleus → Chromatin remodeling@Nucleus
4. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@Nucleus + LIG4:​XLF*:​XRCC4|​hm2@Nucleus + PARP3@Nucleus + DNA-PK*|​hm2|​active@Nucleus + Ku80*@Nucleus + Ku70*@Nucleus + APLF@Nucleus → APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus
5. DNA-PK*|​hm2|​active@Nucleus + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@Nucleus + Ku70*:​Ku80*@Nucleus + PARP3@Nucleus → Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus

1. gA_NHEJ_DNA_st1*@Nucleus → gA_NHEJ_DNA_st2*@Nucleus
2. M phase@Nucleus → G1 phase@Nucleus
3. gC_NHEJ_DNA_st3*@Nucleus → gC_NHEJ_DNA_st4*@Nucleus
4. gC_NHEJ_DNA_st4*@Nucleus → gC_NHEJ_DNA_st5*@Nucleus