Identifiers
DNA with deaminated, alkylated, mistmached base
Damage caused by Alkylating agents or x-rays
Node_Type:Generic
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / BER
References
PMID:23892398
PMID:22258607, PMID:22918414
PMID:23473643, PMID:23408852
References
ce_re511( Cell Cycle DNA Repair ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
For BER activation by IR
PMID:19414382, PMID:21204762, PMID:20832016, PMID:17892593
For BER activation by ROS
PMID:23249296, PMID:22122466, PMID:20510258, PMID:21251944, PMID:23311711
ce_re5( Cell Cycle DNA Repair ):
9-1-1 complex activates TDG glycosylase and activates BER:
PMID:17855402
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
ce_re37( Cell Cycle DNA Repair ):
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle
ce_re178:( Cell Cycle DNA Repair ) reactionType:is.a
ce_re260( Cell Cycle DNA Repair ):
Damaged DNA triggers ATR/ATRIP complex activation
→ gDamaged_DNA*@Nucleus
→ gC_NHEJ_DNA_st1*@Nucleus
→ gA_NHEJ_DNA_st1*@Nucleus
→ gHR_DNA_st1*@Nucleus
→ gBER_M-glyc_DNA_st2*@Nucleus + Base@Nucleus
→ gDeaminated_alkylated_mismatched_base*@Nucleus
→ gSingle_strand_breaks_SSB*@Nucleus