Identifiers
polycystic kidney disease 1 (autosomal dominant)
HUGO:PKD1 HGNC:9008 ENTREZ:5310 UNIPROT:P98161
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
su_mpk1_mpk1_re266( Survival ):
PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth. Signaling proteins with pleckstrin-homology (PH) domains accumulate at sites of PI3K activation by directly binding to PI(345)P3. Of particular interest are the protein serine-threonine kinases Akt and phosphoinositide-dependent kinase 1 (PDK1). Association with PI(345)P3 at the membrane brings these proteins into proximity and facilitates phosphorylation of Akt by PDK1. This phosphorylation stimulates the catalytic activity of Akt resulting in the phosphorylation of a host of other proteins that affect cell growth cell cycle entry and cell survival.
PMID:12040186
su_mpk1_mpk1_re264( Survival ):
PDK1 is a PI3K target leading to activation of P70 (through phosphorylation) and subsequent cell growth.
P70 activation requires both ERK cascade and PI3K/AKT cascade at least in some cell types.
PMID:12040186 PMID:11940578 PMID:10601235 PMID:11431469
References
su_mpk1_mpk1_re266( Survival ):
PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth. Signaling proteins with pleckstrin-homology (PH) domains accumulate at sites of PI3K activation by directly binding to PI(345)P3. Of particular interest are the protein serine-threonine kinases Akt and phosphoinositide-dependent kinase 1 (PDK1). Association with PI(345)P3 at the membrane brings these proteins into proximity and facilitates phosphorylation of Akt by PDK1. This phosphorylation stimulates the catalytic activity of Akt resulting in the phosphorylation of a host of other proteins that affect cell growth cell cycle entry and cell survival.
PMID:12040186