Identifiers
ribosomal protein S6 kinase 70kDa polypeptide 1
"ribosomal protein S6 kinase 70kD polypeptide 1" STK14A
HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443
HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / PI3K_AKT_MTOR 

References
PMID:16286006
PMID:20647036
PMID:11108711

References
su_mpk1_mpk1_re264( Survival  ):
PDK1 is a PI3K target leading to activation of P70 (through phosphorylation) and subsequent cell growth.
P70 activation requires both ERK cascade and PI3K/AKT cascade at least in some cell types.
PMID:12040186 PMID:11940578 PMID:10601235 PMID:11431469

References
su_mpk1_mpk1_re264( Survival  ):
PDK1 is a PI3K target leading to activation of P70 (through phosphorylation) and subsequent cell growth.
P70 activation requires both ERK cascade and PI3K/AKT cascade at least in some cell types.
PMID:12040186 PMID:11940578 PMID:10601235 PMID:11431469
su_mpk1_mpk1_re280( Survival  ):
PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth.
PMID:12040186

References
s_akt1_re68:( Survival  ) PMID:16286006
s_akt1_re71( Survival  ):
PMID:21233202
PMID:12713446
s_akt1_re73:( Survival  ) PMID:17053147
s_akt1_re79( Survival  ):
PMID:18423201
PMID:19339977
s_akt1_re86:( Survival  ) PMID:19720745
s_akt1_re110:( Survival  ) PMID:15905173
s_akt1_re114:( Survival  ) PMID:17052453
s_akt1_re198:( Survival  ) PMID:20832730

References
s_akt1_re66:( Survival  ) PMID:16286006

1. p70_alpha_*@Cytoplasm
2. p70_alpha_*|​pho@Cytoplasm
3. p70_alpha_*|​T389_pho@Cytoplasm
4. p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm

1. 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm
2. DEK:​REF*:​RNPS1:​SKAR*:​SRM160*:​Y14*:​p70_alpha_*|​T389_pho|​T229_pho@Cytoplasm
3. 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm

1. (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm + 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm → 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm
2. 4E-BP*:​EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm → EIF3*:​EIF4E*:​M7GTP*:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm + p70_alpha_*|​T389_pho@Cytoplasm + 4E-BP*|​T37_pho|​T46_pho|​S65_pho|​T70_pho@Cytoplasm
3. p70_alpha_*|​T389_pho@Cytoplasm → p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm
4. DEK:​REF*:​RNPS1:​SRM160*:​Y14*@Cytoplasm + SKAR*@Cytoplasm + p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm → DEK:​REF*:​RNPS1:​SKAR*:​SRM160*:​Y14*:​p70_alpha_*|​T389_pho|​T229_pho@Cytoplasm
5. DEK:​REF*:​RNPS1:​SKAR*:​SRM160*:​Y14*:​p70_alpha_*|​T389_pho|​T229_pho@Cytoplasm → mRNA translation@Cytoplasm
6. p70_alpha_*@Cytoplasm → p70_alpha_*|​pho@Cytoplasm
7. p70_alpha_*|​pho@Cytoplasm → Proliferation@Cytoplasm

1. MTOR@Cytoplasm → MTOR|​pho@Cytoplasm
2. GSK3_beta_*@Cytoplasm → GSK3_beta_*|​pho@Cytoplasm
3. CUL1:​RBX1:​RICTOR@Cytoplasm → CUL1:​RBX1:​RICTOR|​T1135_pho@Cytoplasm
4. EIF4B@Cytoplasm → EIF4B|​pho@Cytoplasm
5. RPS6|​S247_pho@Cytoplasm → RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cytoplasm
6. EIF4A*:​PDCD4@Cytoplasm → EIF4A*:​PDCD4|​S67_pho@Cytoplasm
7. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft → MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft