Gene IDH3A map

Identifiers
HUGO:IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
HUGO:IDH3A HGNC:5384 ENTREZ:3419 UNIPROT:P50213

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
 Cancer Associated Fibroblasts  map  / METABOLIC  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
CASCADE:TGFB
PMID:25732824
CAFs from tumor samples exhibit low levels of IDH3??, and overexpression of IDH3?? prevents transformation of fibroblasts into CAFs.
DH3?? downregulation occurred mainly through transcriptional regulation downstream of TGFB

gIDH3A@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re902:( Regulated Cell Death  map ) PMID:18046414

Modifications:
In compartment: Cytosol
  1. gIDH3A@Cytosol map
In compartment: Nucleus
  1. gIDH3A@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gIDH3A@Cytosol map → map rIDH3A@Cytosol map
    2. gIDH3A@Nucleus map → map rIDH3A@Nucleus map
    As Catalyser: