Complex ARP2_3*:Actinin*:BCAR1:FAK1*:PXN:Talin*:c-SRC*
Complex composition:
- ARP2_3*
- Actinin*
- c-SRC*
- PXN
- Talin*
- BCAR1
- FAK1*
ARP2_3*:Actinin*:BCAR1:FAK1*|Y_pho|pho:PXN|pho:Talin*:c-SRC*@Cytosol
Identifiers
NAME:ARP2_3*:Actinin*:BCAR1:FAK1*:PXN:Talin*:c-SRC*
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence
/ EMT_REGULATORS
EMT Senescence
/ ECM
EMT Senescence
/ CELL_MATRIX_ADHESIONS
References
PMID:12473693
PMID:14749719
PMID:15094799
Vinculin recruits Arp2_3 complex to new sites of focal adhesions to nucleate new actin filaments, promoting actin polymerization.
Modifications:
Participates in complexes:
In compartment: Cytosol
- ARP2_3*:Actinin*:BCAR1:FAK1*|Y_pho|pho:PXN|pho:Talin*:c-SRC*@Cytosol
Participates in reactions:
As Reactant or Product:- ARP2_3*@Cytosol
+ Actinin*:BCAR1:FAK1*|Y_pho|pho:PXN|pho:Talin*:c-SRC*@Cytosol
→
ARP2_3*:Actinin*:BCAR1:FAK1*|Y_pho|pho:PXN|pho:Talin*:c-SRC*@Cytosol
- ARP2_3*:Actinin*:BCAR1:FAK1*|Y_pho|pho:PXN|pho:Talin*:c-SRC*@Cytosol
→
Actin polymerization@Nucleus
As Catalyser: