→ PXN|pho@Cytosol References
PMID:16919435
PMID:16000375
Upon autophosphorylation of FAK, a signaling complex of FAK, CSK binds to and can phosphorylate various adaptor proteins such as p130Cas and paxillin.
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility