Phenotype Cell-matrix adhesions map
Cell-matrix adhesions@default

References
mo_re105:( motility  map ) PMID:23418787 PMID:16472776 PMID:28284838
mo_re148:( motility  map ) PMID:16472776 PMID:19930715 PMID:23092334 PMID:28284838

Cell-matrix adhesions@Cytosol

References
mo_re64:( motility  map ) PMID:18078820

Cell-matrix adhesions@Extracellular space

Identifiers
CELL_MATRIX_ADHESIONS

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
Laminin-8 interacts with integrins.
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
em_emtc_emtc_re713( EMT Senescence  map ):
PMID:8522586
PMID:8207064
Implication of ERM proteins in the regulation of cell-cell and cell-matrix adhesion:
Suppression of all three ERM proteins with antisense oligonucleotides disrupts cell-cell and cell-matrix adhesion
ERM family members are involved in cell-cell and cell-substrate adhesion, as well as microvilli formation.
PMID:9265657
ERM proteins can reconstitute stress fiber assembly, cortical actin polymerization and focal complex formation in response to activation of Rho and Rac

Modifications:
In compartment: Cytosol
  1. Cell-matrix adhesions@Cytosol map
In compartment: Extracellular space
  1. Cell-matrix adhesions@Extracellular space map
In compartment: default
  1. Cell-matrix adhesions@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Laminin 1 partners*:​Laminin1*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    2. Elastin partners*:​Elastin*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    3. Galectin 3 partners*:​Galectin 3*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    4. Collagen1 partners*:​Collagen1*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    5. COL2A1:​Collagen2 partners*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    6. Fibronectin partners*:​Fibronectin*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    7. ERM*|​open@Cytosol map → map Cell-matrix adhesions@Extracellular space map
    8. Laminin8*:​a6b1*_a6b4*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    9. Vitronectin*:​aVb3*_aVb5*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    10. Fibronectin*:​a5b1*_aVb3*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    11. Laminin1*:​a2b1*_a3b1*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    12. COL4A1:​a2b1*_a3b1*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    13. Collagen1*:​a1b1*_a2b1*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
    14. mo_s1 → map Cell-matrix adhesions@default map
    15. FAK*|​pho:​PXN|​pho:​Vinculin*:​others*@Cytosol map → map Cell-matrix adhesions@default map
    16. mo_s7 → map Cell-matrix adhesions@default map
    17. Cell-matrix adhesions@default map → map MAPK pathway@Cytosol map
    18. Cell-matrix adhesions@Cytosol map → map Adhesion@Cytosol map
    19. Cell-matrix adhesions@default map → map Adhesion@Cytosol map
    20. Actin fibers*:​EZR|​Thr 567_pho@Cytosol map → map Cell-matrix adhesions@Cytosol map
    As Catalyser: