Reaction heterodimer_association em_emtc_emtc_re981 map

PXN|​pho@Cytosol map + CRK@Cytosol map + DOCK1@Cytosol map DOCK1:​PXN|​pho@Cytosol map

No reaction regulators

References
PMID:16000375
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility
PMID:15308668
CRK bound to DOCK1 (so-called DOCK180) forms complex with phosphorylated paxillin.
The complex is necessary for collagen-dependent cell migration, mainly through Rac1 activation.