Protein Talin* map

Identifiers
Talin*
talin 1
HUGO:TLN1 HGNC:11845 ENTREZ:7094 UNIPROT:Q9Y490
talin 2
HUGO:TLN2 HGNC:15447 ENTREZ:83660 UNIPROT:Q9Y4G6

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map

References
Identifiers_end

Talin*@Cytosol

References
em_emtc_emtc_re978( EMT Senescence  map ):
Autophosphorylation of PTK2:
PMID:7529872
PMID:19339212
PMID:7657702
PMID:16919435
FAK (PTK2) is first recruited to sites of integrin clustering via interactions wiith integrin-associated proteins such as talin, paxillin.
FAK binds to the cytoplasmic domain of b1 integrin via Paxillin (PXN) and Talin (TLN)
Binding to aVb3 or a5b1 integrins induces PTK2 (FAK1) autophosphorylation at Y397.
PMID:10545505
FAK associates with paxillin, vinculin, and p130cas (BCAR1) in the focal adhesion complex
Integrins control motile strategy through a Rho-cofilin pathway.
beta1 integrins promote random migration, whereas beta3 integrins promote persistent migration in the same epithelial cell background.
Adhesion to fibronectin by aVb3 supports actin cytoskeletal reorganization via cofilin, resulting in a single broad lamellipod with static cell-matrix adhesions at the leading edge.
Adhesion by a5b1 instead leads to the phosphorylation and thus inactivation of cofilin, and these cells fail to polarize their cytoskeleton but extend thin protrusions containing highly dynamic cell-matrix adhesions in multiple directions.
The activity of the small GTPase RhoA is particularly high in cells adhering by a5b1, and inhibition of Rho signaling causes a switch from a beta1 to a beta3-associated mode of migration, whereas increased Rho activity has the opposite effect.
Alterations in integrin expression profiles thus allow cells to modulate several critical aspects of the motile machinery through Rho GTPases.

Modifications:
In compartment: Cytosol
  1. Talin*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. Talin partners*:​Talin*@Cytosol map
  2. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  3. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  4. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​ZYX:​c-SRC*@Cytosol map
  5. ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Talin partners*@Cytosol map + Talin*@Cytosol map → map Talin partners*:​Talin*@Cytosol map
  2. Talin*@Cytosol map → map TLN1@Cytosol map
  3. Talin*@Cytosol map → map TLN2@Cytosol map
  4. FAK1*|​Y_pho|​pho:​c-SRC*@Cytosol map + BCAR1@Cytosol map + Talin*@Cytosol map + PXN|​pho@Cytosol map + Vinculin*@Cytosol map → map BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  5. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map + Actinin*@Cytosol map + Actin cytoskeletal*@Cytosol map → map Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  6. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map + ZYX@Cytosol map → map Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​ZYX:​c-SRC*@Cytosol map
  7. ARP2_3*@Cytosol map + Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map → map ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  8. ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map → map Actin polymerization@Nucleus map
As Catalyser:
  1. FAK1*|​emp@Cytosol map → map FAK1*|​pho@Cytosol map